Romee, Fehniger and colleagues demonstrated that stimulation with the cytokines interleukin-12 (IL-12), IL-15, and IL-18 produces so-called cytokine-induced memory-like (CIML) NK cells that exhibited a 56% overall response rate and 44% complete response rate in treatment of acute myeloid leukemia (46–48). The gene discussed is IL18; the disease is acute myeloid leukemia.