In contrast, the unique genes in the OTM group included Ddit3, Il1r2, Mmp9, Stfa2, and Stfa3, with the distinguishing feature of ‘allergy’ and ‘endopeptidase regulation’, which revealed the activation of macrophages after OTM (Figure 6B and Figure S4A). The gene discussed is DDIT3; the disease is Allergy.