Several TFs were also shared between the two diseases, including JUN, NFKB1, RUNX1 and RELA, that regulated both MS- and RA-associated disease genes (Figure 4E), whereof JUN was in our previously derived core TFs that we predicted to significantly regulate P4 induced gene expression through promoters and distal elements. Here, NFKB1 is linked to rheumatoid arthritis.