More in-depth analysis showed that several upstream TFs were shared between MS and RA such as JUN, ETS1, NFATC1 and NFKB1. NCATC1 controls proliferation and survival of peripheral lymphocytes and NFATC1 deficiency has been shown to ameliorate the course of EAE and has been suggested as a potential treatment option (51). This evidence concerns the gene NFKB1 and rheumatoid arthritis.