Thus, ART (i) can reduce HIV viral RNA loads to below detectable levels (93, 94), (ii) can increase the circulating number of CD4+ T-cells (95, 96), (iii) can reduce the incidence of AIDS-related disease and/or death (95, 97), and (iv) can effectively prevent the transmission of HIV to uninfected people (98). The gene discussed is CD4; the disease is AIDS.