CD4 and cancer: (45), found that latent reservoirs (CD4+ T-cells) from HIV-untreated individuals were predominantly central/transitional memory (Tcm/tm, CD27+ CD45RA-) and Tem (CD27- CD45RA-) when stimulated with bryostatin [an antineoplastic drug used in clinical cancer trials (73), and also used as an LRA (65)], or not.