A strong intratumoral heterogeneity exists in RCC for the expression of ICPs, such as PD-L1, B7-H3, PD-L2 and HLA-G, in primary RCC lesions with a highly variable HLA-G expression either between patients’ tumor samples or at different areas within a tumor tissue (36, 108). The gene discussed is PDCD1LG2; the disease is renal cell carcinoma.