The expression of LILRB1/ILT2 and LILRB2/ILT4 on different immune effector cells, endothelial cells and tumor cells and the effects of the interaction with HLA-G have been recently summarized by Carosella and co-authors (31), while the different affinities of the HLA-G receptors to HLA-G as ligand and the exact binding positions have been reviewed elsewhere (26). This evidence concerns the gene LILRB1 and neoplasm.