In numerous in vitro studies, the downregulation of HLA-G protein levels, e.g. by overexpression of HLA-G regulatory miRs (63), by HLA-G-specific CRISPR/Cas9 systems (125) or by simple inhibition of HLA-G with antibodies (96), resulted in an increased lysis of tumor cells by immune effector cells. The gene discussed is HLA-G; the disease is neoplasm.