We observed 91.9% (68/74) of LN patients with positive anti-DFS70 antibodies had PLN, while in LN patients without anti-DFS70 antibodies, the frequency of PLN was 79.5% (241/303, P=0.013), which was significantly lower than LN patients with positive anti-DFS70 antibodies. This evidence concerns the gene PSIP1 and lobular neoplasia.