A previous large cohort study (10) measured anti-DFS70 antibodies using a uniform chemiluminescence immunoassay and found that the prevalence of anti-DFS70 in their SLE patient cohort was higher compared to SLE patients from previous studies that used HEp-2 IFA to identify DFS pattern/anti-DFS70 antibodies (7.1% vs 0.0%-2.8%). The gene discussed is PSIP1; the disease is systemic lupus erythematosus.