Similarly, EVs derived from M2 polarized tumor-associated macrophages (M2-TAMs) containing MIR17HG and miR-17-92 cluster components are taken up by HCC cells, which induce an imbalance in TGF-β1/BMP-7 pathways, thus enhancing HCC progression (22). Here, TGFB1 is linked to hepatocellular carcinoma.