In total, 544 cases based on TCGA-HNSCC transcriptomic data were analyzed, including 500 tumor tissues and 44 normal tissue samples, revealing that the expression of 18 m6A regulator genes was higher in tumor tissues than that in normal tissues, including 7 m6A writer genes (VIRMA, RBM15, METTL3, WTAP, CBLL1, METTL14, and LRPPRC), 9 reader genes (IGF2BP1, HNRNPC, HNRNPA2B1, YTHDF1, ELAVL1, FMR1, YTHDF3, YTHDF2, and YTHDC1) and 2 erasers genes (ALKBH5 and FTO) (Figures 2A, B). Here, LRPPRC is linked to head and neck squamous cell carcinoma.