Then, risk scores were calculated for every cancer sample calculated by using the following formula: Riskraw = DAD1*2.316+CYCS*1.426+CSNK2A2*1.576+VPS25*0.728+VDAC1*0.976+TMLHE*0.381+CYTH3*0.024+PRKCA*0.260-TP73*0.567+FZD6*0.047+SQSTM1*0.094-MAP2K7*3.070. The gene discussed is TMLHE; the disease is cancer.