HLA-G and cancer: HLA-G expression in cancer microenvironment was regulated by several intracellular and extracellular mechanisms mediated by microRNAs, RNA-binding proteins, heat shock proteins, cytokines, et al. There are several microRNAs were correlated with the expression of HLA-G, such as miR-133a, miR-148a, miR-148b, miR-152, miR-199b-5p, miR-548q and miR-628-5p et.al, mainly investigated in vitro (26–28).