The involved cell types include T cells (γδ T cells, and CD4+ and CD8+ αβ T cells), B cells, NK cells, dendritic cells, monocytes/macrophages, neutrophils, endothelial cells, fibroblasts, eosinophils, basophils), tumor cells, and pathogen cells (e.g., viruses, bacteria, and parasites) (9, 18, 20–28). Here, CD4 is linked to neoplasm.