As expected, SLE neutrophils, but not HC neutrophils, cocultured with an alveolar epithelial cell line induced high levels of ER stress and genes associated with inflammation in the lung such as Il8 and Il16, suggesting an important role for neutrophils in driving ER stress and inflammation in lung epithelial cells in the context of SLE. This evidence concerns the gene CXCL8 and systemic lupus erythematosus.