Quantifying the cluster membership demonstrated a trend that those cells with higher expansion levels were located in cluster 1 for acute, 5 for chronic, 2 for latent infection (Supplementary Figure S17B), which characteristically expressed Zeb2, Tox, and Klrg1, respectively (Figures 1B, F and Supplementary Figure S2). The gene discussed is TOX; the disease is disease arising from reactivation of latent virus.