Quantifying the proportion of cells in each cluster demonstrated that the transcriptional profiles were highly reproducible across biological replicates (Figure 1E and Supplementary Figures S1D, S1E), with CD8+ T cells found in distinct clusters for acute LCMV (clusters 0,1,3,4), chronic LCMV (5,6,7,8), and latent MCMV (0,1,2,6) infections. Here, CD8A is linked to infection.