Further unbiased investigation into the most expressed genes per cluster revealed a plethora of genes previously reported in the context of viral infections, such as Il7r, Tcf7, Zeb2, Klrg1, Gzma, Gzmb, Gzmk, Vim, Lgals3, Tox, Lag3, Pdc1, Id3 (Figure 1B and Supplementary Figures S2, S3, S4). This evidence concerns the gene LAG3 and viral infectious disease.