As NK cells are at the forefront of antiviral response, particularly at that of the respiratory system (53), NK hyporesponsiveness may delay SARS‐CoV‐2 viral recognition and, subsequently, generate an inadequate immune response, supporting the virus propagation and lung damage, such as seen in severe pneumonia with a genetically predicted HLA-C low expression (54). The gene discussed is HLA-C; the disease is pneumonia.