Connective tissue growth factor/Cysteine-rich protein/Nephroblastoma overexpressed-5 (CCN5), coiled-coil domain-containing protein 80 (CDCC80), netrin-1 (NTN1), von Willebrand factor (vWF), dickkopf-related protein 4 (DKK4), sclerostin (SOST), and receptor tyrosine-protein kinase erbB-3 (ERBB3) were significantly decreased in CDMS CSF relative to non-MS while insulin growth factor-like family member 4 (IGL4) and immunoglobulin kappa variable 1-5 (IGKV1-5) were increased (Table 3). Here, IGKV1-5 is linked to myeloid sarcoma.