AKT1 and cancer: Our functional enrichment analysis showed that autophagy- and ferroptosis-related genes were significantly enriched in extracellular matrix (ECM), cancer-related pathways (PI3K-Akt signaling pathway, MAPK signaling pathway, EGFR tyrosine kinase inhibitor resistance, transcriptional misregulation in cancer and estrogen signaling pathway) and ferroptosis (Figure 10A), indicating the potential clinical implications of these genes.