CD4 and cancer: For specimens with high FPI in concert with high API, activities of most of the steps in the cycle were found to be up-regulated, including priming and activation (step 3), B cell recruiting (step 4), CD4+ T cell recruiting (step 4), CD8+ T cell recruiting (step 4), dendritic cell recruiting (step 4), NK cell recruiting (step 4), T cell recruiting (step 4), Th1 cell recruiting (step 4), Th2 cell recruiting (step 4), Treg cell recruiting (step 4) and killing of cancer cells (step 7; Figures 8F, G).