EIF2AK2 and viral infectious disease: In other cases of A-to-I editing in virus infection, suppression of innate immune IFN responses after virus infection is mainly mediated by cytoplasmic dsRNA sensors protein kinase R (PKR) and oligoadenylate synthetase (OAS; Yang et al., 2014; Radetskyy et al., 2018; Lamers et al., 2019).