Though the anti-inflammatory effects of statins have been reported in traumatic brain injury, HFD-induced renal injury, endothelial dysfunction, and cardiac and adipose tissue (Golia et al., 2014; Xu et al., 2017; Yamada et al., 2017; da Silva et al., 2018; Pengrattanachot et al., 2020), it has been reported that statins can induce insulin resistance via activation of caspase-1/IL-1β inflammasomes in adipose tissue (Henriksbo et al., 2019) and Ator could trigger liver toxicity in diabetic rats by promoting the generation of inflammation (Zeng and Liu, 2019). This evidence concerns the gene CASP1 and endothelial dysfunction.