CASP1 and Insulin resistance: Though the anti-inflammatory effects of statins have been reported in traumatic brain injury, HFD-induced renal injury, endothelial dysfunction, and cardiac and adipose tissue (Golia et al., 2014; Xu et al., 2017; Yamada et al., 2017; da Silva et al., 2018; Pengrattanachot et al., 2020), it has been reported that statins can induce insulin resistance via activation of caspase-1/IL-1β inflammasomes in adipose tissue (Henriksbo et al., 2019) and Ator could trigger liver toxicity in diabetic rats by promoting the generation of inflammation (Zeng and Liu, 2019).