The upregulated DEGs in FFPE samples of ACC included genes previously reported to be upregulated in ACC, such as CCNB2 (encoding cyclin B2), TOP2A (encoding DNA topoisomerase II alpha), and MAD2L1 (encoding mitotic arrest deficient 2 like 1) (Table 1 and Supplementary Table 2) (22–24). This evidence concerns the gene TOP2A and adrenal cortex carcinoma.