MOTS-c (58) can regulate glucose and lipid metabolism by targeting specific activation of AMPK in skeletal muscle, regulate coronary endothelial function, enhance cardiac systolic function, improve coronary artery microvascular disorders, etc. SHLP2 and SHLP3 can also improve insulin sensitivity and glucose metabolism in vivo and in vitro, thus contributing to the efficacy of diabetes and its complications. This evidence concerns the gene INS and diabetes mellitus.