CAG8 and CAG14, mainly containing B. vulgatus, were stronger inhibited in the A group and had a positive correlation with the levels of LH/FSH ratio, testosterone, hyperinsulinemia, insulin resistance, BMI, inflammatory factors, and leptin, while they were negatively correlated with the levels of adiponectin and spexin. The gene discussed is ADIPOQ; the disease is Hyperinsulinemia.