Furthermore, we found that MS patients with intrathecal CD4+ T-cell reactivity against GDP-L-fucose synthase derived peptides and that are characterized by higher neuroinflammation and neurodegeneration, also showed higher frequencies of CD28+ CD27- TEMRA and EM CD4+ T cells expressing Th1- and cytotoxicity-associated genes (31). Here, CD4 is linked to myeloid sarcoma.