Furthermore, data supporting a role of Th1 cells in MS are: (i) an increased autoproliferation of CM- and EM CD4+ Th1 cells (32), (ii) higher frequency of myelin basic protein (MBP)-specific Th1+ CD4+ T cells in patients with MS (33), (iii) higher sensitivity of naive CD4+ CD45RA+ to activation by MBP (34), and (iv) involvement of a Th1 axis between T cells and CD11c+ B cells in MS (35). This evidence concerns the gene CD4 and myeloid sarcoma.