Supporting the assumption that markers of T-cell senescence might be useful to identify pathogenic T cells in MS, it is important to note that CD28+ CD27- EM CD4+ T cells with a proinflammatory Th1 functional phenotype that were significantly more frequent in patients of group 3 showed a correlation with the intrathecal amount of NF-L, a biomarker of CNS damage. Here, CD4 is linked to myeloid sarcoma.