CD274 and nervousness: MS is an autoimmune disease of the central nervous system (CNS) (13), in which the expression of PDL-1 in brain lesions (14), the association of PD-1 gene polymorphisms with disease progression (15), the downregulation of PD-1/PD-L1 on peripheral blood mononuclear cells (16), and the increased frequency of PD1+ T cells in patients during remission (12) support an involvement of T-cell exhaustion in disease pathogenesis.