Active SCC stimulation generally increased Hb connectivity with a number of depression-implicated brain areas such as the anterior (specifically rostral and dorsal anterior cingulate cortex, lying outside of the direct stimulation target area) and posterior cingulate cortices, medial prefrontal cortex, dorsolateral prefrontal cortex, superior temporal gyrus, and fusiform gyrus. The gene discussed is GSTM1; the disease is depressive disorder.