Increased levels of hepatic triglyceride lipase (HTGL) have also been associated with IR, which may result in faster HDL-c clearance and lower HDL-c levels (Baynes et al., 1991; Sparks et al., 2012), ultimately causing hypertriglyceridemia and reduced HDL-c values. Here, DDHD2 is linked to hypertriglyceridemia.