In a variety of populations, including men and women with diabetes, glucose intolerance, obesity, sedentary moderately overweight, metabolic syndrome, and T2DM, recent studies have consistently shown that moderate aerobic exercise for 30 min or more three times per week for at least 8 weeks improves insulin sensitivity (Bird and Hawley, 2016). This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.