TRPV1 and glaucoma: Later, Ward et al. (2014) pointed out that either TRPV1 knockout or pharmacological inhibition of the channel could accelerate optic nerve axonopathy with elevated IOP and increase the membrane depolarization indispensable for RGCs to generate action potentials, therefore TRPV1 may boost excitatory activity as a means of promoting RGCs survival in glaucoma.