The main molecular signaling pathway by which autophagy exerts its multifunctional role during liver fibrosis is through Phosphoinositide 3-kinase/Protein kinase B (PKB), also known as Akt/mammalian Target of Rapamycin (PI3K/Akt/mTOR) (reviewed in Wang H. et al., 2019). Here, AKT1 is linked to Hepatic fibrosis.