Although there are discrepancies regarding the role of autophagy as a promoter or inhibitor of liver fibrosis, there are several lines of evidence that PI3K/Akt/mTOR pathway is a major molecular mechanism that is regulated from upstream signals such as growth factors, energy status, oxygen levels (Saxton and Sabatini, 2017). The gene discussed is AKT1; the disease is Hepatic fibrosis.