When analyzed individually with IPA, the top FoxO dependent canonical pathways (Supplementary Table 3, Sheet 2) were most enriched for protein kinase A signaling, sirtuin signaling (which includes many OXPHOS and other mitochondrial genes), cancer-related, cardiac hypertrophy, PPARα/RXRα activation, and mitochondrial dysfunction (Figure 4C). This evidence concerns the gene PPARA and cancer.