A proteomics study revealed that three derivatives from Gamboge, namely, gambogic acid (GA), gambogenic acid (GEA) and 1,3,6,7-tetrahydroxyxanthone (TTA), inhibited HCC cell proliferation and induced apoptosis by regulating stathmin 1 (STMN1) and 14-3-3σ. This evidence concerns the gene STMN1 and hepatocellular carcinoma.