Dai et al. confirm that ECH affects Protein kinase-like endoplasmic reticulum kinase (PERK), inhibits the PERK/eIF2α pathway to reduce ERS, and regulates F-actin remodeling to reduce the excessive accumulation of Aβ and the expression of BACE1 protein by using immunohistochemistry, Aβ plaque load quantification, Aβ ELISA, RNA isolation, quantitative PCR, Western blot analysis, BACE1 activity assay and Transmission Electron Microscopy in APPswe/PS1dE9 (2 × Tg-AD) mice (Dai et al., 2020). Here, BACE1 is linked to Alzheimer disease.