AKT1 and Parkinson disease: ECH can significantly improve the neurobehavior of PD mice by upregulating the survival signal p-AKT/AKT The expression of mTOR inhibits the expression of mTOR, thereby promoting the clearance of α-synuclein and the degradation of the autophagy substrate P62, exerting a neuroprotective effect (Zhang et al., 2021b).