GATA4-S105A mice did not exhibit cardiac hypertrophy induced by 2 weeks of PE infusion with decreased expression of Nppa, Nppb and Myh7, signifying that extracellular signal-regulated kinase 1/2 and p38 MAPK dependent phosphorylation of GATA4 were required for fetal gene reactivity in hypertrophic hearts (van Berlo et al., 2011). Here, GATA4 is linked to cardiac hypertrophy.