More importantly, we elucidated the potential role of PZH in mediating CRC immune escape and in synergistically enhancing anti-PD-1/PD-L1 immunotherapy, which depends on PZH attenuating PD-L1 expression via suppressing IFNGR1-JAK1-STAT3-IRF1 signaling. This evidence concerns the gene CD274 and colorectal carcinoma.