PD-1/PD-L1 blocking antibody indeed elevates the effector function of CD8+ T cells in the short term, while activated effector T cells release a large amount of IFNγ to kill tumor cells, leading tumor cells to evade the surveillance of immune system through the inherent resistance mechanisms (Vesely et al., 2011; Garcia-Diaz et al., 2017). This evidence concerns the gene IFNG and neoplasm.