CD19 and systemic sclerosis: Furthermore, recent findings have emphasized that the frequency of CD19+IgD−CD27+CD38−CD95+–activated switched memory (ASM) B cells in the peripheral blood of patients with dcSSc was lower than that in the HC, mostly in individuals with anti–Scl-70 antibodies or pulmonary fibrosis, implying that the ASM B cells were associated with severe SSc (Simon et al., 2021).