Therefore, to study the treatment of CIN and cervical cancer by restoring p53 expression and inactivating HPV oncoprotein, and to verify the effectiveness of nano drugs based on nucleic acid delivery in cancer treatment, we attempted to reverse cervical intraepithelial neoplasia by vaginal injection of nanoparticles composed of PBAE537 and plasmids (wild-type p53 expression and HPV16 E7 targeting), providing a new idea strategy for precise treatment of cervical cancer. The gene discussed is TP53; the disease is cervical intraepithelial neoplasia.