GAD1 and Alzheimer disease: There was an increase in GAD67 in astrocytes AD tissue, indicative of increased GABA levels in reactive astrocytes of CA1 and DG of the APPNL-F/NL-F mouse model when compared to wild-type control mice (Figure 1F) by, 638.04 ± 64.80% in CA1, and by, 400.26 ± 44.24% in DG (n = 5, ****p ≤ .0001).