Our key findings corroborate other studies in the field, which show an enhanced inflammatory response as a result of reactive astrocytes, correlating with an elevated expression of GAD67 and GAT3/4 in hippocampal regions in AD models (Kersanté et al., 2013; Wu et al., 2014; Heneka et al., 2015; Carter et al., 2019). The gene discussed is GAD1; the disease is Alzheimer disease.