In addition, the concentrations of IL-6 in patients with severe COVID-19 was usually tens of pg/mL, which was similar to our results and far lower than those in patients with septic shock or CRS induced by Chimeric Antigen Receptor (CAR) T-cell infusion (Aziz et al., 2020; Monneret et al., 2021). The gene discussed is IL6; the disease is congenital rubella syndrome.