In general, these findings together confirm that alpinetin exerts considerable therapeutic effects on multitudinous inflammatory diseases, including acute lung injury, mastitis, colitis, osteoarthritis, delayed-type hypersensitivity, allergic asthma, COPD, endometritis, and PICS mainly via suppression of NF-κB and excitation of PPAR-γ, Nrf2/HO-1, AhR, and PXR. This evidence concerns the gene NFKB1 and osteoarthritis.