Huo et al. originally appraised that alpinetin markedly downregulated tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) expression levels in lipopolysaccharide (LPS)-irritated RAW 264.7 macrophages in vitro and LPS-provoked acute lung injury mice model in vivo. Here, IL6 is linked to acute lung injury.