Briefly, alpinetin directly promoted Treg differentiation in CD4+T cells of mesenteric lymph nodes (MLNs), restored Th17/Treg balance in colons, and then inhibited symptoms of colitis in vivo through elevating AhR expression and coordinating miR-302/DNMT-1/CREB signaling pathway (Lv et al., 2018). Here, AHR is linked to colitis.