Brain natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) were two hormones secreted by the myocardial cell against myocardial fibrosis and hypertrophy, and cardiomyopathy and cardiac failure can be ruled out if their level was normal. The gene discussed is NPPB; the disease is Myocardial fibrosis.