Further, CB2 selective agonists have been shown to ameliorate autoimmune reactions in a variety of mouse models that include experimental autoimmune encephalitis (EAE) (a model for multiple sclerosis) (Ni et al., 2004; Maresz et al., 2007), systemic sclerosis (Akhmetshina et al., 2009; Servettaz et al., 2010), autoimmune uveoretinitis (Xu et al., 2007), murine colitis and inflammatory bowel disease (Storr et al., 2009; Singh et al., 2012; Fichna et al., 2014; Leinwand et al., 2017). Here, CNR2 is linked to multiple sclerosis.