By comparing different studies, we found that IL-6, TNF, RELA, MAPK1, MAPK8, CXCL8, IL1B, MAPK14, TP53, CCL2, IL-2, PTGS2, and IFNG were the key targets for HSBD treatment of COVID-19 (Lai et al., 2020; Liu et al., 2020; Tao et al., 2020; Xie et al., 2020; Niu et al., 2021; Zhu et al., 2021). This evidence concerns the gene TP53 and COVID-19.