As more mechanisms of osteoporosis were discovered and novel techniques had been developed to help better understand about the micro-structure of bone, there are several effective therapies for osteoporosis treatment including bisphosphonates, elective estrogen, and RANKL inhibitor such as denosumab (Khosla and Hofbauer, 2017; Choksi et al., 2018), as well as teriparatide (Chotiyarnwong and McCloskey, 2020). This evidence concerns the gene TNFSF11 and osteoporosis.