MAPT and Alzheimer disease: Therefore, substantial research has been ongoing to develop imaging probes against aggregated Aβ (Ono et al., 2003, 2011; Cui et al., 2011; Watanabe et al., 2011; Rajasekhar et al., 2016, 2017) and more recently tau (Cui et al., 2011; Matsumura et al., 2012) to improve diagnostic accuracy and neuropathological characterization of AD.