MAPT and Alzheimer disease: In addition to tau and Aβ aggregates, a significant proportion of AD patients also display α-syn (Lippa et al., 1998; Hamilton, 2000; Marui et al., 2000; Rosenberg et al., 2000; Arai et al., 2001; Jellinger, 2003, 2004; Parkkinen et al., 2003; Trembath et al., 2003; Popescu et al., 2004; Ol et al., 2006; Uchikado et al., 2006) and TDP-43 (Amador-Ortiz et al., 2007; Higashi et al., 2007; Hu et al., 2008; Uryu et al., 2008; Arai et al., 2009; Kadokura et al., 2009; King et al., 2010; Josephs et al., 2014) aggregates.