Activation of choline acetyltransferase (ChAT) neurons in the basal forebrain with theta burst stimulation that alleviates the decay in cholinergic synaptic transmission effectively protects against spatial pattern separation impairment in the mice with AD, and this protection was completely abolished by inhibiting the hippocampus newly generated immature neuron survival (Zhu et al., 2017). Here, CHAT is linked to Alzheimer disease.