The Cardiovascular Health Study cohort predicted increased mortality in the cases with combined cognitive and gait impairments, showing structural, functional, or pathological alterations in common areas of the brain, along with the upregulated inflammatory markers, particularly interleukin-6 (IL-6), even in the patients with or without signs of dementia (Rosano et al., 2008; Nagga et al., 2014). The gene discussed is IL6; the disease is dementia.