CASP1 and Parkinson disease: Wang et al. (2016) demonstrated that caspase-1 can be found at the core of Lewy bodies extracted from human PD patients’ brains. In this study, they stained Lewy bodies for caspase-1 and α-syn and showed a caspase-1 positive core (∼10 microns in diameter) surrounded by α-syn (Wang et al., 2016).