NLRP3 and neurodegenerative disease: The nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome is one of the most well characterized sensors of danger signals in cells, most associated with neurodegenerative diseases, and serves as a connection point between neuronally-derived misfolded protein aggregates and the damaging neuroinflammation associated with neurodegeneration (de Alba, 2019; Swanson et al., 2019).