Comparison of the transcriptome of tdTomato-positive interneurons isolated from 23-week-old control and KCC2 KOPV mice revealed major changes in genes involved in PI3K-Akt signaling and MAPK signaling (Figures 7B,C), some of which have been linked with epilepsy previously (Berdichevsky et al., 2013; Pernice et al., 2016; Carter et al., 2017). The gene discussed is AKT1; the disease is epilepsy.