Notably, KCC2 loss-of-function mutations in humans are associated with inherited febrile seizures, severe genetic generalized epilepsy and epilepsy of infancy with migrating focal seizures (Hubner, 2014; Kahle et al., 2014; Puskarjov et al., 2014; Kahle et al., 2016; Saitsu et al., 2016; Di Cristo et al., 2018). This evidence concerns the gene SLC12A5 and Seizure.