TARDBP and amyotrophic lateral sclerosis: Over the past few years there has been growing evidence for a primary role of TDP-43 in muscle tissue as well, as pathological TDP-43 aggregates are found in muscle tissues from patients with myopathies (sIBM, IBMPFB, OPMD, DMRV and myofibrillar myopathies) and ALS patients alike.