GPNMB and ocular hypertension: While no DBA/2J-Gpnmb+/SjJ mice developed ocular hypertension, IOPs over 21 mm Hg were seen in DBA/2J mice for 5 out of 40 eyes (from 3 animals) at 9 months and in 11 out of 20 eyes (from 8 animals) at 12 months (Figure 3B).