GPNMB and ocular hypertension: Taken together these findings indicate that while increasing levels of IPD as an anterior chamber abnormality are highly correlated with the development of increased IOP and ultimately ocular hypertension, the development of corneal calcification as an anterior chamber abnormality in both DBA/2J-Gpnmb+/SjJ and DBA/2J mice was independent of changes in IOP over time.