At the same time, we measured a moderate but clinically relevant generalized increase in qualitative corneal calcification with age in both DBA/2J and DBA/2J-Gpnmb+/SjJ mice (Figure 5), where at age 12 months the degree of corneal calcification was not statistically significantly different between the two strains when assessed qualitatively (Figure 5B) or quantitatively (Figures 6A–D). The gene discussed is GPNMB; the disease is calcification.