GPNMB and ocular hypertension: IOP increased in a statistically significant manner from 6 to 9 months of age and then again more pronounced from 9 to 12 months in DBA/2J mice, with ocular hypertension developing and continuing after 43 weeks of age (Figure 3), a time-course pattern of IOP increase that is consistent with previous reports (Libby et al., 2005; Williams et al., 2013; Wang and Dong, 2016) and that is absent in DBA/2J-Gpnmb+/SjJ mice.