PCOS patients had excess androgen levels with increased LH and attenuated periodic female hormone secretion, such as significantly higher levels of testosterone, LH and LH/FSH (2.34-, 1.81-, and 1.91-fold compared to the control, respectively, P < 0.001), and lower levels of estradiol and progesterone (65.0% and 30.08% lower, respectively, P < 0.001) (Table 1). The gene discussed is PLOD1; the disease is polycystic ovary syndrome.