Several studies have reported intrinsic resistance to VEN, including overexpression of antiapoptotic BCL-2 family members other than BCL-2,5 acquired mutations in the BCL-2 binding groove found in chronic lymphocytic leukemia (CLL),6 amplifications of BCL2,2,6,7 and alterations in the mitochondria structure and metabolic changes.8 This evidence concerns the gene BCL2 and B-cell chronic lymphocytic leukemia.