NRAS and acute myeloid leukemia: Gene expression profiles of RNA extracted from Sca1+ spleen cells of the mutant NRAS/BCL-2 high risk myelodysplastic syndrome (HR-MDS) and the AML post MDS mouse models showed significant upregulation of genes coding for components of the major complexes of the mitochondrial electron transport chain (ETC) including genes of complex I, IV for HR-MDS model and Complex I, II, III, IV, and V for AML post MDS model11.