FADS1 and heart failure: For example, lower plasma PC(36:4) was associated with: higher NAS in children; hepatic steatosis in adults (from Mann et al. (18)); all-cause mortality, diabetes, and cardiac failure in adults (from Pietzner et al. (19)); and, variants in FADS1-2-3, which are also independently linked to death from cardiovascular disease (Table 1).