To further investigate whether the up-regulation of lncRNA RGMB-AS1 expression was related to the inhibition of cell biological behavior in NPC, while the silencing of lncRNA RGMB-AS1 expression had the opposite effect, we silenced and overexpressed lncRNA RGMB-AS1, and preliminarily confirmed the possible mechanism of lncRNA RGMB-AS1 on NPC cell biological behavior. Here, RGMB is linked to nasopharyngeal carcinoma.